{"id":21893,"date":"2024-01-24T06:00:01","date_gmt":"2024-01-24T05:00:01","guid":{"rendered":"https:\/\/www.intimina.com\/blog\/?p=21893"},"modified":"2024-01-24T06:00:13","modified_gmt":"2024-01-24T05:00:13","slug":"hypothalamic-amenorrhea-period-loss","status":"publish","type":"post","link":"https:\/\/www.intimina.com\/blog\/hypothalamic-amenorrhea-period-loss\/","title":{"rendered":"Hypothalamic Amenorrhea and What Causes Period Loss"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Did you know that your brain \u2014 specifically, the hypothalamus \u2014 can impact your period? It&#8217;s a lesser-known condition called hypothalamic amenorrhea and is when a person does not menstruate due to an imbalance in the brain&#8217;s control center.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In fact, this condition impacts <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6374026\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">1.62 million women<\/span><\/a><span style=\"font-weight: 400;\"> in the United States and 17.4 million globally.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Primary vs. secondary amenorrhea<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Primary amenorrhea is when someone does not start their period by the age of 16 years old. This means they have never had a period at all.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The cause of primary amenorrhea may be a chromosomal or genetic abnormality that prevents the ovaries from functioning normally. Some people may have a condition known as Turner syndrome, which is when someone is missing \u2014 either partially or totally \u2014 an X chromosome. The syndrome can cause infertility, heart problems, and alter someone&#8217;s appearance. This syndrome may contribute to the cause of a missing period.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Secondary amenorrhea is when a period is missing for at least three months or more. Other symptoms include depression, insomnia, fatigue, immense hunger, vaginal dryness, low sex drive, hair loss, and headaches.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Not having a period can cause short and long-term issues like not being able to get pregnant, a decline in bone health, higher risk of cardiovascular disease, depression, anxiety, hair loss, and acne.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Secondary amenorrhea can be caused by pregnancy, menopause, certain birth controls like an IUD, medications, chemotherapy, polycystic ovary syndrome, thyroid problems, or pituitary tumors.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to a <\/span><a href=\"https:\/\/www.mayoclinicproceedings.org\/article\/S0025-6196(23)00282-3\/fulltext\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">study published in <\/span><i><span style=\"font-weight: 400;\">Mayo Clinic Proceedings<\/span><\/i><\/a><span style=\"font-weight: 400;\">, one-third of secondary amenorrhea patients have hypothalamic amenorrhea. Let&#8217;s dive into the condition and how it can impact someone&#8217;s life.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How is the hypothalamus related to menstruation?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Your hypothalamus is the control center of the brain. You may remember hearing about it in science class. It regulates your temperature, your feelings of hunger, your mood, your sex drive, and even your blood pressure, <\/span><a href=\"https:\/\/www.endocrine.org\/clinical-practice-guidelines\/hypothalamic-amenorrhea\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">according to the Endocrine Society<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The hypothalamus releases a gonadotrophin-releasing hormone (GnRH) which signals the follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estrogen to control menstruation in the body. FSH and LH are responsible for your ovary releasing an egg.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When the hypothalamus doesn&#8217;t produce GnRH, your body is thrown out of wack and this could lead to the disappearance of your period.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Why might the body stop releasing GnRH? There are varying reasons but they include not eating enough food, having an eating disorder, exercising too much, having low body fat, emotional stress, or having poor nutrition.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">With .2 to 4 percent of young women and adult women living with an <\/span><a href=\"https:\/\/www.uptodate.com\/contents\/functional-hypothalamic-amenorrhea-pathophysiology-and-clinical-manifestations\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">eating disorder<\/span><\/a><span style=\"font-weight: 400;\">, finding treatment as soon as possible is essential. Moreover, many young women participate in a form of exercise, but they do not often keep up with their caloric intake, putting them at high risk for the condition. Eating disorders include anorexia, bulimia, and binge eating disorder.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The brain believes that the body is in immense distress and it essentially goes into survival mode.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The majority of women with this condition severely restrict their caloric intake or exercise two to three hours a day. And it&#8217;s <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2941235\/#:~:text=FHA%20is%20estimated%20to%20affect,seeking%20evaluation%20for%20secondary%20amenorrhea.&amp;text=It%20is%20also%20more%20commonly,clinical%20and%20subclinical%20eating%20disorders.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">common in athletes<\/span><\/a><span style=\"font-weight: 400;\"> who have a low body mass index (BMI).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For athletes, usually participating in a sport like ballet, figure skating, gymnastics, and cross-country running, this condition can cause irreversible bone loss and stress fractures, according to a <\/span><a href=\"https:\/\/journals.healio.com\/doi\/10.3928\/00904481-20160210-03\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">study published in <\/span><i><span style=\"font-weight: 400;\">Pediatric Annals<\/span><\/i><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Diagnosing and testing for hypothalamic amenorrhea<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It&#8217;s difficult to look at someone and know they have this condition. It&#8217;s also difficult for the patients themselves to know they have imbalanced hormones or low estrogen.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A healthcare practitioner will want to rule out other conditions before diagnosing hypothalamic amenorrhea, like polycystic ovary syndrome, pregnancy, or adrenal gland disorders.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A doctor will provide a blood test to check hormone levels, a pelvic exam, have the patient take a pregnancy test, or conduct an MRI of the pituitary gland, which is an endocrine gland that releases hormones.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Hormonal blood tests measure the levels of FSH, LH, human chorionic gonadotropin (hCG), and prolactin. If the blood work shows low levels of FSH and LH, this may indicate hypothalamic amenorrhea. If the blood work comes back with high levels of prolactin, this may mean the patient has a benign tumor on the pituitary gland.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To prepare for your doctor&#8217;s visit, write down any details about your symptoms and the date of your last period. Bring in any key medical information and be honest about any supplements you&#8217;re taking. The doctor will also want to know about your family history so make sure to review any information that can be helpful.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Treatment<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">For most people, a doctor will suggest a lifestyle change. Since many people who have the condition are exercising or limiting food intake, doctors will recommend limiting exercise, working on gaining weight or finding a way to reduce stress.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Patients with an eating disorder or high stress may benefit from seeing a mental health professional. With .2 to 4 percent of young women and adult women living with an <\/span><a href=\"https:\/\/www.uptodate.com\/contents\/functional-hypothalamic-amenorrhea-pathophysiology-and-clinical-manifestations\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">eating disorder<\/span><\/a><span style=\"font-weight: 400;\">, finding treatment as soon as possible is essential. Moreover, many young women participate in a form of exercise, but they do not often keep up with their caloric intake, putting them at high risk for the condition.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Those struggling with stress, which can have a huge impact on reproductive function, may also benefit from seeing a therapist or looking to control their stress factors.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Treatment varies from person to person and the length of time will depend on many factors like age, weight, and genetics. On average, it takes a person three to six months for their period to return, however, this is a very broad generalization.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you don&#8217;t have a period for three months and are growing concerned, contact your healthcare provider for an appointment. Typically, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7418467\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">71 percent<\/span><\/a><span style=\"font-weight: 400;\"> of patients fully recover.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is important, however, to know that this condition is reversible and can be managed if the patient implements a nutritious diet, weight, and livelihood.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Did you know that your brain \u2014 specifically, the hypothalamus \u2014 can impact your period? It&#8217;s a lesser-known condition called hypothalamic amenorrhea and is when a person does not menstruate&hellip;<\/p>\n","protected":false},"author":45,"featured_media":21790,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[2],"tags":[283,47,224],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.12 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hypothalamic Amenorrhea and What Causes Period Loss - Intimina<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.intimina.com\/blog\/hypothalamic-amenorrhea-period-loss\/\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Nicole Lane\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.intimina.com\/blog\/hypothalamic-amenorrhea-period-loss\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.intimina.com\/blog\/hypothalamic-amenorrhea-period-loss\/\"},\"author\":{\"name\":\"Nicole Lane\",\"@id\":\"https:\/\/www.intimina.com\/blog\/#\/schema\/person\/29c2f34c8cb617d8a8bd643e37e8d7d3\"},\"headline\":\"Hypothalamic Amenorrhea and What Causes Period Loss\",\"datePublished\":\"2024-01-24T05:00:01+00:00\",\"dateModified\":\"2024-01-24T05:00:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.intimina.com\/blog\/hypothalamic-amenorrhea-period-loss\/\"},\"wordCount\":987,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.intimina.com\/blog\/#organization\"},\"keywords\":[\"irregular period\",\"menstruation\",\"women's health\"],\"articleSection\":[\"Menstruation\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.intimina.com\/blog\/hypothalamic-amenorrhea-period-loss\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.intimina.com\/blog\/hypothalamic-amenorrhea-period-loss\/\",\"url\":\"https:\/\/www.intimina.com\/blog\/hypothalamic-amenorrhea-period-loss\/\",\"name\":\"Hypothalamic Amenorrhea and What Causes Period Loss - Intimina\",\"isPartOf\":{\"@id\":\"https:\/\/www.intimina.com\/blog\/#website\"},\"datePublished\":\"2024-01-24T05:00:01+00:00\",\"dateModified\":\"2024-01-24T05:00:13+00:00\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.intimina.com\/blog\/hypothalamic-amenorrhea-period-loss\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.intimina.com\/blog\/#website\",\"url\":\"https:\/\/www.intimina.com\/blog\/\",\"name\":\"Intimina\",\"description\":\"A Health and Wellness Resource for Women\",\"publisher\":{\"@id\":\"https:\/\/www.intimina.com\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.intimina.com\/blog\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.intimina.com\/blog\/#organization\",\"name\":\"Intimina\",\"url\":\"https:\/\/www.intimina.com\/blog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.intimina.com\/blog\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.intimina.com\/blog\/wp-content\/uploads\/2019\/04\/INTIMINA_logo-02.png\",\"contentUrl\":\"https:\/\/www.intimina.com\/blog\/wp-content\/uploads\/2019\/04\/INTIMINA_logo-02.png\",\"width\":1000,\"height\":543,\"caption\":\"Intimina\"},\"image\":{\"@id\":\"https:\/\/www.intimina.com\/blog\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/intimina\",\"https:\/\/twitter.com\/intimina\",\"https:\/\/www.instagram.com\/intimina\/\",\"https:\/\/www.pinterest.com\/intimina\/\",\"https:\/\/www.youtube.com\/channel\/UCR_3_GPO6pkhDiFU9TZRdYA\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.intimina.com\/blog\/#\/schema\/person\/29c2f34c8cb617d8a8bd643e37e8d7d3\",\"name\":\"Nicole Lane\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.intimina.com\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/90740ee540ff9ed51255b66aac77856d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/90740ee540ff9ed51255b66aac77856d?s=96&d=mm&r=g\",\"caption\":\"Nicole Lane\"},\"description\":\"S. 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